Evolving genetic code

نویسندگان

  • Takeshi OHAMA
  • Yuji INAGAKI
  • Yoshitaka BESSHO
  • Syozo OSAWA
چکیده

In 1985, we reported that a bacterium, Mycoplasma capricolum, used a deviant genetic code, namely UGA, a "universal" stop codon, was read as tryptophan. This finding, together with the deviant nuclear genetic codes in not a few organisms and a number of mitochondria, shows that the genetic code is not universal, and is in a state of evolution. To account for the changes in codon meanings, we proposed the codon capture theory stating that all the code changes are non-disruptive without accompanied changes of amino acid sequences of proteins. Supporting evidence for the theory is presented in this review. A possible evolutionary process from the ancient to the present-day genetic code is also discussed.

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عنوان ژورنال:

دوره 84  شماره 

صفحات  -

تاریخ انتشار 2008